Note number of veins by inspecting inferior vena cava along entire length of kidney. (Courtesy of Karl T. Rew, MD) Introduction Synonyms Epidemiology The main symptom is severe sharp pain that starts suddenly, usually in your belly or one side of your back, and it may go away just as quickly. Retrograde urogram shows a calculus in the left ureter. Each end of the kidney is commonly called a pole. I hope this helps. The patient had acute renal failure; therefore, contrast-enhanced CT was not performed. Estimated creatinine clearance may be calculated using serum creatinine with adjustments made for sex, age, and body weight. But more often, kidney cysts are a type called simple kidney cysts. Read more. Typically, one kidney sits on either side of your spine. Table 18-7 lists causes of unilateral smooth renal atrophy. Because the fascia of the retroperitoneum prevents significant extravasation, the incision usually heals to form a larger lumen. Enlargement of a congenitally unilateral kidney is typical and presumed to be compensatory. Urine that is concentrated in the renal papilla is subsequently excreted into a lumen lined with transitional epithelium. The region where the renal pelvis joins the ureter is called the ureteropelvic junction (UPJ). Table 18-7 lists causes of unilateral smooth renal atrophy. B, Mild hydronephrosis results in rounding of the fornices with mild shortening of the papillary impression. Horseshoe kidneys result from midline fusion of the kidneys, typically at the level of the origin of the inferior mesenteric artery. Pain that radiates to the lower abdomen and groin. Because the fascia of the retroperitoneum prevents significant extravasation, the incision usually heals to form a larger lumen. BOX 18-1 Cockroft and Gault Equation for Calculating Estimated Creatinine Clearance. Figure 18-2 Annotated axial image of the right kidney from a contrast-enhanced computed tomographic scan demonstrates hilar anatomy of the kidney. On the other hand, babies with bilateral agenesis cannot survive without an immediate kidney transplant. This method is the standard in evaluation of UPJ obstruction and often is used for other types of chronic obstruction. For most people, obstruction of a single ureter does not induce renal failure. Unilateral renal agenesis occurs in approximately 1 in 1000 individuals with minimal impact on health, although it is sometimes associated with other congenital anomalies of the genitourinary tract and musculoskeletal system. A, Enhancement of the mass is conspicuous in the corticomedullary phase. Each nephron contains a renal corpuscle, which is the initial component that filters the blood, and a renal tubule that processes and carries the filtered fluid to the system of calyces. The kidneys are highly vascular (contain a lot of blood vessels) and are divided into three main regions: the renal cortex (outer region which contains about 1.25 million renal tubules), renal medulla (middle region which acts as a collecting chamber), and renal pelvis (inner region which receives urine through the major calyces). On the superior aspect of each kidney is the adrenal gland. A. Junctional cortical line seen on a long-axis ultrasound image of the right kidney. Concerning lymphatic drainage, each kidney drains into the lateral aortic (lumbar) lymph nodes, which are placed around the origin of the renal artery. Figure 18-1 Annotated three-dimensional volume rendering of the left kidney acquired using a combined nephrographic phase and excretory phase during computed tomographic urography demonstrates regional anatomy of the kidney. The nephrons within the cortex comprise some of the most highly perfused parenchymal tissue in the body. Chronic obstruction, however, results in damage to the papilla, evident in the clubbed calyx of papillary necrosis (Fig. In this way, the consistency of blood is preserved and no important substances are lost. The kidneys are located between the transverse processes of T12-L3 vertebrae, with the left kidney typically positioned slightly more superiorly than the right. Extraaortic origin of the renal arteries and accessory renal arteries are common. Occasionally, a papilla will communicate directly with an infundibulum or the renal pelvis and is considered to be an aberrant papilla. Look carefully for accessory arteries at upper and lower poles (Fig. Figure 18-10 Crossed ectopia on intravenous pyelogram. Crossed ectopia can be either fused or unfused. It is also permeable for the products of the metabolism, such are creatinine and drug metabolites. 18-25). MR angiography can be useful for the diagnosis of renal vascular abnormalities. When abnormal echogenicity is detected, it is important to note whether it is unilateral or bilateral. B, Transverse image of the bladder demonstrates a large bladder tumor in the region of the trigone. Pearl: Any upward trend in serum creatinine value should be viewed with concern because it implies renal reserve function has already been affected. Since the abdominal organs are not paired, the left kidney is not related to the same organs as the right kidney. Kenhub. In this region, the anterior and posterior. So the pyramids represent the functional tissue that creates urine, whereas the calyces are the beginning of the ureter and transport the urine to it. Obstruction can cause renal failure if it is bilateral (Box 18-3) or if there is preexisting disease in the unobstructed kidney. The ureters are the tubes that carry urine from the renal pelvis to the bladder. However, you may have symptoms related to the condition that's causing it. They extend from lumbar vertebra T12-L3. Figure 25.1.2 Left Kidney. 18-10). However, this individual is more likely to show a decline in renal function from an additional insult. Note that there is no contrast in the aorta. 18-4). 18-1). Look for retroaortic or circumaortic left renal vein. Differential diagnosis General imaging considerations include: renal cortical defect duplex kidney 18-21). 18-22). In this case, the right kidney had more favorable anatomy for laparoscopic donor nephrectomy. The goal of imaging patients with renal failure is to identify a correctable cause in an effort to recover or preserve renal function. Ultrasound to get images of your kidneys. Note that there is no contrast in the aorta. Unlike the excretory phase of enhanced CT, signal intensity within the renal collecting systems is reduced on T1- and T2-weighted MR images once excreted gadolinium-based contrast media becomes sufficiently concentrated. Ultrasound It can be seen as a triangular echogenic cortical defect, frequently seen in upper lobe parenchyma. This refers to the forming of the stones within the system of calyces because of too much calcium or uric acid into the filtrate. The hilum of the kidney usually projects at the level of the L2 vertebra. For that reason, we got you covered with this topic nicely and concisely. Figure 18-16 Coronal reformation from contrast-enhanced computed tomography performed for renal donation demonstrates a retroaortic left renal vein crossing the aorta well inferior to the level of the renal hila. 18-16). The kidneys can be divided into three main regions from cranial to caudal. Caliectasis doesn't cause any symptoms on its own. Thus, any upward trend in the serum creatinine value should be viewed with concern when considering the administration of potentially nephrotoxic or renally excreted intravenous contrast media. Increasing pressure within the lumen initially distends the fornices (acutely angled portions of the calyx along the sides of the papillae), whereas the central portion of the papillary impression is preserved. Renal Cysts. But here is a neat little mnemonic to help. 18-20). The pyramids are separated by extensions of the cortex called the renal columns. T2-weighted maximum intensity projection image from a magnetic resonance urogram performed to evaluate urinary obstruction identified in a patient with an obstructing soft tissue mass in the pelvis on unenhanced computed tomography (CT). This illustrates the amount of reserve function that must be compromised before renal injury can be detected with a serum creatinine level. The fused kidneys can have a variety of orientations, including side by side, in-line, or perpendicular. aware of such a vessel, the urologist may choose to perform an alternate procedure to avoid hemorrhagic complications. The kidneys serve important . Each end of the kidney is commonly called a pole. CT scan and MRI to help diagnose and stage kidney masses. The kidneys are a pair of bean-shaped organs located below the rib cage, one on each side of the spine. C, More severe hydronephrosis results in more pronounced shortening of the papilla. Learn more about the anatomy of the kidneys and the urinary system with our urinary system quizzes and labeled diagrams. The main unit of the medulla is the renal pyramid. Diabetes, hypertension, acute tubular necrosis, Increased echogenicity has high association with parenchymal disease, Acute tubular necrosis usually results in an increased RI, whereas prerenal causes usually do not have an increased RI; postrenal causes often increase the RI, but hydronephrosis should be present in those cases, If present, suspect neurogenic bladder or outlet obstruction, Often severe aortic disease or fibromuscular dysplasia. The left kidney appeared unremarkable. The apex of the pyramid projects medially toward the renal sinus. This causes them to fire impulses which stimulate rhythmical contraction and relaxation, called peristalsis. 18-1). Approximately 1 year before presentation, the patient experienced a similar episode of right flank pain that prompted an unenhanced CT examination of the abdomen and pelvis at an outside institution. 18-14). 18-4). Chronic obstruction, however, results in damage to the papilla, evident in the clubbed calyx of papillary necrosis (Fig. Supernumerary kidneys are quite rare and have been associated with aortic coarctation, vaginal atresia, and urethral duplications. Renal cysts are sacs of fluid that form in the kidneys. The vessel which brings blood into the glomerulus is the afferent arteriole, whereas the vessel that carries the rest of the blood out that hasnt been filtered out of the glomerulus is called the efferent arteriole. The ureter and calyces were not dilated (not shown), helping to differentiate this anatomic variant from obstruction. This phenomenon is due to T2-shortening and susceptibility (T2*) effects caused by concentrated gadolinium, and can potentially obscure filling defects and urothelial lesions. The renal corpuscle has two components: the glomerular (Bowmans) capsule in which sits the glomerulus. Coronal computed tomographic image in the corticomedullary phase shows normal corticomedullary differentiation along the lobulated contour, consistent with fetal lobulation. Solid masses are more likely to be cancerous but they are not all cancerous. Because repeat imaging does not expose the patient to additional radiation, multiple phases including delayed images may be obtained and allow the creation of quantitative curves that define the initial filling and then clearing of dilated collecting system structures. The nephrons within the cortex comprise some of the most highly perfused parenchymal tissue in the body. Each segmental branch of the renal artery divides into multiple interlobar arteries that course along the periphery of the medullary pyramids and causes small interlobular branches (Fig. Diagnostic ultrasound uses sound wave technology to look at parts of your body, including: Brain Heart and blood vessels Breast Abdominal Organs Eyes Thyroid Skin and muscles Types of Ultrasound. The corticomedullary phase is prolonged in the presence of ureteral or venous obstruction and can persist for days in cases of acute tubular necrosis (ATN; Fig. Learning anatomy is a massive undertaking, and we're here to help you pass with flying colours. development and contrast excretion parallel those seen on contrast-enhanced CT with one notable exception (Fig. Urine that is concentrated in the renal papilla is subsequently excreted into a lumen lined with transitional epithelium. Figure 18-27 T2-weighted maximum intensity projection image from a magnetic resonance urogram performed to evaluate urinary obstruction identified in a patient with an obstructing soft tissue mass in the pelvis on unenhanced computed tomography (CT). The MDRD calculation is more complicated than calculating creatinine clearance (taking into account body surface area, sex, and race) but is thought to be more accurate than estimated creatinine clearance, particularly among the elderly and obese. B, A curved planar reformation of the crossing vein demonstrates its course. Even when there is another plausible explanation for decreased renal function (e.g., known prerenal causes), ultrasound offers the opportunity to rapidly and noninvasively identify a potentially correctible cause of renal failure. Aggressive tumors form, grow and spread very quickly. Both renal arteries, left and right, arise just below the superior mesenteric artery, with the left renal artery positioned slightly superiorly to the right one. The kidneys are positioned retroperitoneally, meaning that they are not wrapped with the peritoneal layers the way most abdominal organs are, but rather are placed behind it. Axial images from contrast-enhanced computed tomography demonstrate transient enhancement of a small renal cell carcinoma. Most diagnosed kidney growths are small and localized masses. Advantages of scintigraphy include accurate quantitative measurement of function. Because production of creatinine is affected by sex, age, muscle mass, protein intake, and liver function, the serum creatinine can be an inaccurate predictor of renal function, particularly in those at the extremes of age and body weight. More tenuous vascular supply to the renal medulla makes it more susceptible to ischemia. D, If pressure on the papilla persists, the ischemic papilla undergoes necrosis, allowing the calyx to protrude outward toward the cortex. There are many clinical states related to kidney malfunction. Figure 18-19 Sagittal ultrasound image of the right kidney demonstrates increased size and echogenicity of the kidney, findings typical of human immunodeficiency virus nephropathy. Other common kidney conditions are acquired through life, and one of the most common is nephrolithiasis (kidney stones). The right kidney had a similar appearance (not shown). Figure 18-4 Illustration demonstrating the relation between the renal papilla and calyx. Jana Vaskovi MD A junctional cortical line is a common septum of capsule typically seen on ultrasound as an echogenic line at the site of fusion between the superior pole and middle third of the kidney (Fig. Learn how we can help 1.2k views Reviewed Dec 09, 2022 Thank Some of them are congenital, such as a third kidney, which is usually atrophic. AMLs can bleed and while not cancerous are still taken very seriously. Bilateral echogenic kidneys with renal hypertrophy can be seen associated with human immunodeficiency virus disease (see. CT and MR findings of renal artery stenosis parallel classic findings described on intravenous pyelogram, including one atrophic kidney with delayed nephrogram and excretion that can progress to a persistent nephrogram with hyperconcentrated excreted contrast media (Fig. The anteromedial aspect of the interpolar region is interrupted by the renal hilum to make a C shape. Best, Susan. Illustration demonstrating the relation between the renal papilla and calyx. Always include unenhanced computed tomographic images to look for renal stones. Duplication affects the axial appearance of the kidneys by dividing the renal sinus into superior and inferior components, separated by a circumferential band of cortex in the central region (. In addition to the renal artery, accessory renal arteries are present too. This can cause varicocele of the left testicle because gravity works against the column of the blood in the left testicular vein. Figure 18-22 Axial images of the left kidney from a three-phase renal computed tomographic scan demonstrate improved conspicuity of low-attenuation lesions of the renal medulla during the nephrographic phase. Normal parenchymal enhancement on CT or MRI allows definitive characterization. In fact, evaluation of the renal collecting system during the excretory phase often requires window and level settings approaching those used for evaluating the osseous structures (Fig. In other cases, each renal unit has its own ureter. If the renal pelvis is entirely within the confines of the renal sinus, it is considered intrarenal. Renal function is better evaluated by measured creatinine clearance, which takes into account not only the amount of creatinine in the blood but also the amount of creatinine within a specified volume of urine over a given period. Overview. Their shape resembles a bean, where we can describe the superior and inferior poles, as well as the major convexity pointed laterally, and the minor concavity pointed medially. The early excretory phase begins as early as 120 seconds after injection. Hypotension is a stimulus for the kidneys to increase the retention of fluid and thus increase blood pressure. It is important to remember this order of vessels and ducts since this is the only thing that will make you able to orient the kidney and differentiate the left one from the right when they are outside of the cadaver. 18-8). When both kidneys are on the same side crossed ectopia is present, because the ureter from one kidney must cross the midline to insert into the bladder (Fig. Right-sided pain was related to crossed renal ectopia. Ultrasound permits real-time optimization of imaging relative to the axis of each kidney. Arterial stenosis was confirmed by magnetic resonance angiography. Although each kidney is about the size of a fist, the approximately one million nephrons per kidney require nearly 20% of the total cardiac output to perform this multitude of functions. Many clinical laboratories now provide computer-generated calculations of estimated creatinine clearance or eGFR using patient data in the medical information system. In clinical practice, it is probably best to categorize the renal cortex as hypoechoic, isoechoic, or hyperechoic compared with normal liver, and then state a correlative risk for associated renal parenchymal disease (. print Print this Article Further testing/diagnosis is required. Because the interlobular arteries form an arch overlying the pyramid, they are called the arcuate arteries. Each time a professor says 'nephron', a student gets a headache. Sagittal ultrasound image of the left kidney demonstrates a unilateral small, smooth, echogenic kidney in a patient with renal artery stenosis. During the 6th to 9th weeks of life, the kidneys begin to ascend from their position in the pelvis to the level of T12-L1, inferior to the adrenal glands. The presence of significant renal parenchyma may justify surgical repair to maximize the functional contribution of that kidney. It can be caused by a variety of factors, but most often arises because of the ischemia of the kidney and the toxic effect of some medications, resulting in the failure of all kidney functions. Blood in the urine, or dark urine. Computed Tomographic Appearance of the Kidneys, Utility of Different Phases of Renal Contrast Enhancement. Advantages of scintigraphy include accurate quantitative measurement of function and parenchymal mass without the risks for nephrotoxicity associated with iodinated contrast media or nephrogenic systemic fibrosis associated with gadolinium contrast agents. In the medulla, 5-8 renal pyramids are separated by connective tissue renal columns. The ureter and calyces were not dilated (not shown), helping to differentiate this anatomic variant from obstruction. Bone scan and chest x-ray to find out if the cancer has spread. Recent advances in MDCT and MRI permit cross-sectional vascular studies to replace conventional angiography before UPJ repair (Fig. The large left proximal ureteral stone seen in this image is only partially obstructing, causing mild dilation in the left kidney collecting system. The most common cause is renal artery stenosis (see Fig. Axial image of the left kidney obtained in the excretory phase of a computed tomographic urogram demonstrates the effects of window settings on visualizing structures near excreted contrast. Parasympathetic innervation enhances the peristalsis while sympathetic innervation inhibits it. Since they are located deep retroperitoneally, the easiest way to examine them is from the patients back. The left testicular vein must ascend higher and it drains to the left renal vein at a right angle, unlike the right testicular vein which joins the inferior vena cava directly. On ultrasound, the renal cortex is usually echogenic in this setting. The uniform high attenuation of the nephrographic phase provides an optimal background for detecting small, low-attenuation lesions in the renal parenchyma (Fig. Any excessive amount of fluid will increase the pressure on the arterial wall and cause the blood pressure to rise (hypertension). Living renal donor allografts account for more than half of the transplanted kidneys in the United States. In most cases, unenhanced CT is performed when the duration and cause of renal failure are unknown because exposure to iodinated contrast media could impair recovery of renal function. The renal pelvis then tapers like a funnel to join the ureter. Causes. The left renal vein passes anteriorly to the aorta just below the trunk of the superior mesenteric artery, which is risky because it can be compressed by one of those two. When abnormal echogenicity is detected, it is important to note whether it is unilateral or bilateral. 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